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. 2006 Feb;50(2):759-61.
doi: 10.1128/AAC.50.2.759-761.2006.

A porphyrin increases survival time of mice after intracerebral prion infection

David A Kocisko  1 , Winslow S Caughey, Richard E Race, Grant Roper, Byron Caughey, John D Morrey
Affiliations

A porphyrin increases survival time of mice after intracerebral prion infection

David A Kocisko et al. Antimicrob Agents Chemother. 2006 Feb.

Abstract

Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.

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Figures

FIG. 1.
FIG. 1.
Structures of the two types of porphyrins tested. Metal-free TAP is shown on the left. The central metal ion of these porphyrins is coordinated with the nitrogen atoms as is shown for FeTSP on the right.
See this image and copyright information in PMC

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