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. 2006 Feb;50(2):803-5.
doi: 10.1128/AAC.50.2.803-805.2006.

Trematocidal activity of praziquantel and artemisinin derivatives: in vitro and in vivo investigations with adult Echinostoma caproni

Jennifer Keiser  1 , Reto Brun, Bernard Fried, Jürg Utzinger
Affiliations

Trematocidal activity of praziquantel and artemisinin derivatives: in vitro and in vivo investigations with adult Echinostoma caproni

Jennifer Keiser et al. Antimicrob Agents Chemother. 2006 Feb.

Abstract

We examined the effects of praziquantel and the artemisinins on adult Echinostoma caproni. In vitro, both praziquantel and the artemisinins exhibited exposure-response relationships. In vivo, worm burden reductions of 100% were achieved with single oral doses of praziquantel, artesunate, and artemether at 50, 700, and 1,100 mg/kg of body weight, respectively.

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Figures

FIG. 1.
FIG. 1.
Chemical structures of artemisinin, artemether, artesunate, arteether, dihydroartemisinin, and praziquantel.
See this image and copyright information in PMC

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