Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Feb 15;531(1-3):280-1.
doi: 10.1016/j.ejphar.2005.12.015. Epub 2006 Jan 24.

The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors

Alessandra Ottani  1 , Sheila Leone, Maurizio Sandrini, Anna Ferrari, Alfio Bertolini
Affiliations

The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors

Alessandra Ottani et al. Eur J Pharmacol. .

Abstract

The mechanism of the analgesic activity of paracetamol (acetaminophen), one of the most widely used drugs for the treatment of pain, is still not clear. Here we show that in rats, using the hot plate test, the analgesic effect of paracetamol is prevented by two antagonists at cannabinoid CB1 receptors (AM281 and SR141716A) at doses that prevent the analgesic activity of the cannabinoid CB1 agonist HU210. Our present results suggest that paracetamol-induced antinociception involves the cannabinoid system.

PubMed Disclaimer

MeSH terms