Review
doi: 10.1016/j.cell.2006.01.010.
DNA double-strand break repair: a relentless hunt uncovers new prey
Affiliations
- PMID: 16439201
- DOI: 10.1016/j.cell.2006.01.010
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Review
DNA double-strand break repair: a relentless hunt uncovers new prey
Cell.
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Free article
Abstract
A major pathway for repair of DNA double-strand breaks is nonhomologous end-joining (NHEJ). In this issue of Cell, and report the discovery of a new NHEJ factor called Cernunnos-XLF. Both groups report that this protein is mutated in a rare inherited human syndrome characterized by severe immunodeficiency, developmental delay, and hypersensitivity to agents that cause DNA double-strand breaks.
Comment on
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Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.Cell. 2006 Jan 27;124(2):287-99. doi: 10.1016/j.cell.2005.12.030. Cell. 2006. PMID: 16439204
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XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.Cell. 2006 Jan 27;124(2):301-13. doi: 10.1016/j.cell.2005.12.031. Cell. 2006. PMID: 16439205
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