doi: 10.1364/ol.31.000193.
Plane-wave fluorescence tomography with adaptive finite elements
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- PMID: 16441027
- DOI: 10.1364/ol.31.000193
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Plane-wave fluorescence tomography with adaptive finite elements
Opt Lett.
.
Abstract
We present three-dimensional fluorescence yield tomography of a tissue phantom in a noncontact reflectance imaging setup. The method employs planar illumination with modulated light and frequency domain fluorescence measurements made on the illumination plane. An adaptive finite-element algorithm is used to handle the ill-posed and computationally demanding inverse image reconstruction problem. Tomographic images of fluorescent targets buried at 1-2 cm depths from the illumination surface demonstrate the feasibility of fluorescence tomography from reflectance tomography in clinically relevant tissue volumes.
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