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Review
. 2006 Jan;83(1):12-6.
doi: 10.1532/IJH97.05117.

CD4+CD3- cells regulate the organization of lymphoid tissue and T-cell memory for antibody responses

Peter J L Lane  1 , Mi-Yeon Kim, Fabrina M C Gaspal, Fiona M McConnell
Affiliations
Review

CD4+CD3- cells regulate the organization of lymphoid tissue and T-cell memory for antibody responses

Peter J L Lane et al. Int J Hematol. 2006 Jan.

Abstract

This review highlights the role of a CD4(+)CD3(-) accessory cell in the development of organized lymphoid infrastructures as well as in the development of high-affinity antibody responses and T-cell memory. These 2 functions are linked in the development of the vertebrate immune system and are effected by the constitutive expression of 2 sets of tumor necrosis factor (TNF) family members. The expression of lymphotoxin 3 (LT3), LT3, and TNF-3, which are closely linked genetically, affects the organization of lymphoid structures into B-cell and T-cell areas; the dual expression of OX40 ligand (TNFSF4) and CD30 ligand (TNFSF8) influences both the survival of T-cells within germinal centers and T-cell memory.

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