Review
doi: 10.1152/physiol.00042.2005.
Development and regulation of dendritic spine synapses
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- PMID: 16443821
- DOI: 10.1152/physiol.00042.2005
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Review
Development and regulation of dendritic spine synapses
Physiology (Bethesda).
2006 Feb.
Free article
Abstract
Dendritic spines are small protrusions from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. They play critical roles in synaptic transmission and plasticity. Recent advances in imaging and molecular technologies reveal that spines are complex, dynamic structures that contain a dense array of cytoskeletal, transmembrane, and scaffolding molecules. Several neurological and psychiatric disorders exhibit dendritic spine abnormalities.
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