Review
doi: 10.1152/physiol.00044.2005.
AMPK: a key sensor of fuel and energy status in skeletal muscle
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- PMID: 16443822
- DOI: 10.1152/physiol.00044.2005
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Review
AMPK: a key sensor of fuel and energy status in skeletal muscle
Physiology (Bethesda).
2006 Feb.
Free article
Abstract
Contraction induces marked metabolic changes in muscle, and the AMP-activated protein kinase (AMPK) is a good candidate to explain these effects. Recent work using a muscle-specific knockout of the upstream kinase, LKB1, has confirmed that the LKB1-->AMPK cascade is the signaling pathway responsible for many of these effects.
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