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Review
. 2006 Feb:21:48-60.
doi: 10.1152/physiol.00044.2005.

AMPK: a key sensor of fuel and energy status in skeletal muscle

D Grahame Hardie  1 , Kei Sakamoto
Affiliations
Free article
Review

AMPK: a key sensor of fuel and energy status in skeletal muscle

D Grahame Hardie et al. Physiology (Bethesda). 2006 Feb.
Free article

Abstract

Contraction induces marked metabolic changes in muscle, and the AMP-activated protein kinase (AMPK) is a good candidate to explain these effects. Recent work using a muscle-specific knockout of the upstream kinase, LKB1, has confirmed that the LKB1-->AMPK cascade is the signaling pathway responsible for many of these effects.

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