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. 2005 Mar-Apr;71(2):202-7.
doi: 10.1016/s1808-8694(15)31311-2. Epub 2005 Aug 2.

Cognitive P300 potential in subjects with Diabetes Mellitus

Kátia de Freitas Alvarenga  1 , Josilene Luciene Duarte, Daniela Polo Camargo da Silva, Raquel Sampaio Agostinho-Pesse, Carlos Antonio Negrato, Orozimbo Alves Costa
Affiliations

Cognitive P300 potential in subjects with Diabetes Mellitus

Kátia de Freitas Alvarenga et al. Braz J Otorhinolaryngol. 2005 Mar-Apr.

Abstract

Diabetes Mellitus may lead to alterations in the eyes, kidneys, cranial nerves, peripheral nerves, ears etc. The cognitive function also seems to be compromised in subjects presented with Diabetes Mellitus, since the cortical and subcortical structures responsible for this function are hindered in some insulin-dependent patients. The cognitive potential P300 has been used as an objective procedure to assess cerebral cognitive functions.

Aim: To analyze the sensitivity of P300 cognitive potential for the detection of alterations on the auditory cortex secondary to Diabetes Mellitus.

Study design: transversal cohort.

Material and method: Sixteen diabetic subjects of both genders aged 7 to 71 years, and seventeen non-diabetic individuals at the same age range participated in this study. The evaluation procedures were pure tone audiometry (PTA) and P300 cognitive potential. Glycemia of the group presented with Diabetes was assessed prior to applying P300.

Results: No statistically significant difference was shown for PTA results. A statically significant difference was observed between groups when analyzing the latency of P300 component measured in Fz. There was a correlation between glycemia and latency and amplitude of P300.

Conclusion: The investigation of the cognitive potential of P300 is an important procedure for prevention and early diagnosis of neurological changes in individuals presented with Diabetes Mellitus.

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Figures

Graph 1
Graph 1
Correlation between latency FZN2 (ms) and glucose level (mg/dl).
Graph 2
Graph 2
Correlation between latency of CZP3 (ms) and glucose level (mg/dl).
Graph 3
Graph 3
Correlation between amplitude of FZP300 (¼v) and glucose level (mg/dl).
See this image and copyright information in PMC

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