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Case Reports
. 1992 Jul;31(4):746-50.
doi: 10.1097/00004583-199207000-00025.

Clomipramine in autism: preliminary evidence of efficacy

C J McDougle  1 , L H Price, F R Volkmar, W K Goodman, D Ward-O'Brien, J Nielsen, J Bregman, D J Cohen
Affiliations
Free article
Case Reports

Clomipramine in autism: preliminary evidence of efficacy

C J McDougle et al. J Am Acad Child Adolesc Psychiatry. 1992 Jul.
Free article

Abstract

This report provides preliminary evidence for the efficacy of clomipramine in the treatment of young adults with autistic disorder. Four of five outpatients with autistic disorder showed significant improvement in social relatedness, obsessive compulsive symptoms, and aggressive and impulsive behavior with clomipramine treatment. These findings are consistent with previous evidence, suggesting that serotonin neurotransmission may be relevant to the treatment, and possibly the pathophysiology, of some symptoms of autistic disorder.

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Comment in

  • Negative results with clomipramine.
    Magen J. Magen J. J Am Acad Child Adolesc Psychiatry. 1993 Sep;32(5):1079-80. doi: 10.1097/00004583-199309000-00035. J Am Acad Child Adolesc Psychiatry. 1993. PMID: 8407757 No abstract available.

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