doi: 10.1021/ja057640s.
Total synthesis of (+/-)-welwitindolinone a isonitrile
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- PMID: 16448105
- DOI: 10.1021/ja057640s
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Total synthesis of (+/-)-welwitindolinone a isonitrile
J Am Chem Soc.
.
Free article
Abstract
A highly stereoselective total synthesis of the alkaloid natural product welwitindolinone A isonitrile has been completed. The synthesis utilizes a chloronium ion mediated semi-pinacol rearrangement to simultaneously install the C10 quaternary center and neopentyl chlorine and a novel anionic cyclization to construct the spiro-oxindole with complete stereocontrol.
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