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Review
. 2006 Feb:209:10-27.
doi: 10.1111/j.0105-2896.2006.00347.x.

Establishment and functioning of intrathymic microenvironments

Graham Anderson  1 , William E Jenkinson, Terry Jones, Sonia M Parnell, Francesca A M Kinsella, Andrea J White, Judit E Pongrac'z, Simona W Rossi, Eric J Jenkinson
Affiliations
Review

Establishment and functioning of intrathymic microenvironments

Graham Anderson et al. Immunol Rev. 2006 Feb.

Abstract

The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.

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