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Case Reports
. 1992;18(3):170-1.
doi: 10.1007/BF01709241.

Chloroquine poisoning: ventricular fibrillation following 'trivial' overdose in a child

G G Collee  1 , G S Samra, G C Hanson
Affiliations
Case Reports

Chloroquine poisoning: ventricular fibrillation following 'trivial' overdose in a child

G G Collee et al. Intensive Care Med. 1992.

Abstract

A 13-year-old boy was admitted to hospital 45 min after the ingestion of approximately 750 mg of chloroquine base. A few minutes after gastric lavage with warm water he developed ventricular fibrillation from which he was promptly resuscitated. The plasma concentration of chloroquine was 4.2 mumol/l; significantly lower than the concentrations previously associated with a fatal outcome in adults. The clinical and electrocardiographic effects of chloroquine poisoning are discussed, and the literature reviewed regarding the role of specific management with diazepam and adrenaline infusions. A period of twenty four hours electrocardiographic (ECG) monitoring and pulse oximetry in an intensive care unit is advocated for all patient with ECG changes following chloroquine overdose.

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