Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2006 Mar;27(3):296-300.
doi: 10.1002/uog.2708.

Meckel-Grüber syndrome: sonography and pathology

V Ickowicz  1 , D Eurin, B Maugey-Laulom, F Didier, C Garel, M C Gubler, A Laquerrière, E F Avni
Affiliations
Free article
Multicenter Study

Meckel-Grüber syndrome: sonography and pathology

V Ickowicz et al. Ultrasound Obstet Gynecol. 2006 Mar.
Free article

Abstract

Objective: To define a specific sonographic pattern for the appearance of the kidneys in fetuses affected by Meckel-Grüber syndrome (MGS).

Methods: This was a retrospective analysis of 30 cases, collected from five centers, with ultrasound features suggestive of MGS. Only fetuses with a confirmed diagnosis of MGS were finally included. Analysis included a detailed evaluation of the sonographic findings and comparison with pathological follow-up.

Results: Seventeen cases met the pathological criteria for a diagnosis of MGS and were included in the study. In all cases, a typical sonographic pattern was seen: the kidneys were enlarged (mean, + 4.8 SD) and showed unusual corticomedullary differentiation, occurring as early as the first trimester. In most cases, the medullary areas appeared excessively large and mottled due to the presence of multiple small cysts.

Conclusions: The kidneys of fetuses with MGS are enlarged, cystic and have unusual corticomedullary differentiation. These features can be observed as early as the first and early second trimesters.

PubMed Disclaimer

Publication types

LinkOut - more resources