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Review
. 1991:86 Suppl 1:99-105.

Remodeling of the heart in chronic pressure overload

Affiliations
  • PMID: 1645166
Review

Remodeling of the heart in chronic pressure overload

B Swynghedauw. Basic Res Cardiol. 1991.

Abstract

Cardiac hypertrophy resulting from a chronic mechanical overload is the physiological adaptation of the heart to a disease. From a physiological point of view it is characterized by a slowing of the maximum unloaded shortening velocity and an increased duration of the action potential. This slowing allows the heart to maintain a normal maximum tension at a slower rate. In addition, the heart produced per gram of tension is normalized and the efficiency returns to normal. From a biological point of view the expression of two protooncogenes and of two heat-shock proteins genes is enhanced at the beginning of the overload. The biological determinants of the changed shortening velocity are species-specific. An isomyosin shift plays a major role in some species, e.g., rat, while in others, e.g., man, changes in membrane proteins are determinant. The density in Ca2+ channels remains unmodified, with a significant drop in the density of Ca2+ ATPase of SR, adrenergic and muscarinic receptors, and a slowing of the Na+/Ca2+ exchange. More complex changes occur at the level of the Na+, K+ ATPase. One of the principal consequences of these findings is that most of the usual targets of inotropes are modified and that new drugs have to be conceptualized accordingly.

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