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. 2005 Dec 30;6 Suppl 1(Suppl 1):S60.
doi: 10.1186/1471-2156-6-S1-S60.

Locally weighted transmission/disequilibrium test for genetic association analysis

Li Hsu  1 , Xuesong Yu, Jeanine J Houwing-Duistermaat, Hae-Won Uh, Rachid El Galta, Jeremie J P Lebrec, Hua Tang
Affiliations

Locally weighted transmission/disequilibrium test for genetic association analysis

Li Hsu et al. BMC Genet. .

Abstract

The transmission/disequilibrium test statistic has been used for assessing genetic association in affected-parent trios. In the presence of multiple tightly linked marker loci where local dependency may exist, haplotypes are reconstructed statistically to estimate the joint effects of these markers. In this manuscript, we propose an alternative to the haplotype approach by taking a weighted average of multiple loci, where the weight is proportional to the product of (1-2X recombination fraction) and the linkage disequilibrium between markers. As an illustration, we applied the method to the simulated Aipotu data.

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Figures

Figure 1
Figure 1
χ2 for TDT (left) and smoothed TDT (right).
See this image and copyright information in PMC

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