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Comment
. 2006 Feb 7;103(6):1659-60.
doi: 10.1073/pnas.0510948103. Epub 2006 Feb 1.

Protein-protein interactions for cancer therapy

Curtis C Harris  1
Affiliations
Comment

Protein-protein interactions for cancer therapy

Curtis C Harris. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Conflict of interest statement: No conflicts declared.

Figures

Fig. 1.
Fig. 1.
Cellular stress, e.g., DNA damage, telomere erosion, hypoxia, or oncogene expression, activates the p53 response pathway. The p53–MDM2 autoregulatory feedback loop governs p53 amounts. Overexpression of MDM2 in human cancer, e.g., gene amplification of MDM2, targets p53 for ubiquitin-dependent protelytic degradation to disable the p53 network. Nutlin-3 complexes with MDM2 and inhibits its interaction with p53.
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