Case Reports
doi: 10.1002/mus.20515.
Cholinergic neuromuscular hyperactivity in patients with myasthenia gravis seropositive for MuSK antibody
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- PMID: 16453324
- DOI: 10.1002/mus.20515
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Case Reports
Cholinergic neuromuscular hyperactivity in patients with myasthenia gravis seropositive for MuSK antibody
Muscle Nerve.
2006 Jul.
Abstract
A 75-year-old man with severe oculobulbar myasthenia gravis (MG) treated with acetylcholine esterase inhibitors (AChEIs) was found to have muscle-specific tyrosine kinase (MuSK) antibodies. Neurophysiological examination displayed extra repetitive discharges after the compound motor action potential (CMAP) at low-frequency stimulation, possibly triggered by AChEI. This indicates an abnormal sensitivity to acetylcholine in patients with MuSK antibodies and may be a useful indicator of the adverse effect of AChEI treatment in these patients.
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