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Review
. 2006 Jan-Feb;22(1):186-98.
doi: 10.1021/bp050208u.

Role of Caco-2 cell monolayers in prediction of intestinal drug absorption

Pranav Shah  1 , Viral Jogani, Tamishraha Bagchi, Ambikanandan Misra
Affiliations
Review

Role of Caco-2 cell monolayers in prediction of intestinal drug absorption

Pranav Shah et al. Biotechnol Prog. 2006 Jan-Feb.

Abstract

The usefulness of Caco-2 cell monolayers in determining the intestinal drug absorption of potential drug candidates as such and from delivery systems, elucidating the underlying mechanisms thereof, presystemic metabolism, cellular uptake and cytotoxicological assessment has been exemplified in this review. The role of Caco-2 cell monolayers in studying the effectiveness, involved mechanism and toxicity of various excipients for drug absorption promotion has also been discussed.

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