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Review
. 2006 Feb;117(2 Suppl Mini-Primer):S450-6.
doi: 10.1016/j.jaci.2005.11.016.

5. IgE, mast cells, basophils, and eosinophils

Calman Prussin  1 , Dean D Metcalfe
Affiliations
Review

5. IgE, mast cells, basophils, and eosinophils

Calman Prussin et al. J Allergy Clin Immunol. 2006 Feb.

Abstract

IgE, mast cells, basophils, and eosinophils constitute essential elements in allergic inflammation. Allergen-specific IgE, synthesized in response to allergens in the environment, becomes fixed to FcepsilonRI on the membranes of mast cells and basophils. Aggregation of receptor-bound IgE molecules on re-exposure to specific allergen results in the production of mediators that produce the allergic response. Principal among the cells drawn to sites of mediator release is the eosinophil.

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