Review
[PI3K-AKT-mTOR pathway inhibitors]
[Article in
French]
Affiliations
- PMID: 16455502
Item in Clipboard
Review
[PI3K-AKT-mTOR pathway inhibitors]
[Article in
French]
Bull Cancer.
2006 Jan.
Free article
Abstract
Molecular targeted agents have enlarged the armamentarium of anti-cancer therapies. Along with the success of some anti-growth factor receptors, signal transduction inhibitors represent a promising anti-cancer strategy. The PI3K-AKT-mTOR pathway is a key pathway frequently altered in cancer cells. This manuscript provides an overview of the PI3K-AKT-mTOR pathway and its targeting in human malignancies. A focus is delivered for mTOR inhibitors.
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