Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease
- PMID: 16455580
- DOI: 10.1080/08916930500484674
Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease
Abstract
Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with streptococcal M protein and cardiac myosin. Recent studies have unraveled the potential pathogenic mechanisms by which the immune response against the group A streptococcus attacks the rheumatic valve leading to chronic rheumatic heart disease. Both B- and T-cell responses are involved in the process, and evidence for the hypotheses of molecular mimicry and epitope spreading are reviewed.
Similar articles
-
T cell mimicry in inflammatory heart disease.Mol Immunol. 2004 Feb;40(14-15):1121-7. doi: 10.1016/j.molimm.2003.11.023. Mol Immunol. 2004. PMID: 15036918 Review.
-
Autoimmunity and molecular mimicry in the pathogenesis of post-streptococcal heart disease.Front Biosci. 2003 May 1;8:s533-43. doi: 10.2741/1067. Front Biosci. 2003. PMID: 12700052 Review.
-
Molecular pathogenesis of rheumatic fever and rheumatic heart disease.Expert Rev Mol Med. 2005 Dec 8;7(28):1-15. doi: 10.1017/S146239940501015X. Expert Rev Mol Med. 2005. PMID: 16336741 Review.
-
Streptococcus and rheumatic fever.Curr Opin Rheumatol. 2012 Jul;24(4):408-16. doi: 10.1097/BOR.0b013e32835461d3. Curr Opin Rheumatol. 2012. PMID: 22617826 Free PMC article. Review.
-
T cell mimicry and epitope specificity of cross-reactive T cell clones from rheumatic heart disease.J Immunol. 2005 Oct 15;175(8):5448-56. doi: 10.4049/jimmunol.175.8.5448. J Immunol. 2005. PMID: 16210652
Cited by
-
The pathophysiological basis of pharmacological interventions in CAVD.Neth Heart J. 2012 Jun;20(6):270-8. doi: 10.1007/s12471-011-0230-1. Neth Heart J. 2012. PMID: 22160992 Free PMC article.
-
The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?Medicina (Kaunas). 2023 Sep 8;59(9):1629. doi: 10.3390/medicina59091629. Medicina (Kaunas). 2023. PMID: 37763748 Free PMC article. Review.
-
Heart Failure in Chronic Infectious and Inflammatory Conditions: Mechanistic Insights from Clinical Heterogeneity.Curr Heart Fail Rep. 2022 Oct;19(5):267-278. doi: 10.1007/s11897-022-00560-3. Epub 2022 Jul 15. Curr Heart Fail Rep. 2022. PMID: 35838874 Free PMC article. Review.
-
Identification of streptococcal m-protein cardiopathogenic epitopes in experimental autoimmune valvulitis.J Cardiovasc Transl Res. 2014 Mar;7(2):172-81. doi: 10.1007/s12265-013-9526-4. Epub 2013 Dec 18. J Cardiovasc Transl Res. 2014. PMID: 24346820 Free PMC article.
-
IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae of Streptococcus pyogenes.Front Cardiovasc Med. 2023 Feb 6;9:919700. doi: 10.3389/fcvm.2022.919700. eCollection 2022. Front Cardiovasc Med. 2023. PMID: 36815140 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical