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Case Reports
. 2006 Feb;44(2):595-7.
doi: 10.1128/JCM.44.2.595-597.2006.

Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis

Francisco M Marty  1 , Wendy W Yeh, Christine B Wennersten, Lata Venkataraman, Esperanza Albano, Edwin P Alyea, Howard S Gold, Lindsey R Baden, Satish K Pillai
Affiliations
Case Reports

Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis

Francisco M Marty et al. J Clin Microbiol. 2006 Feb.

Abstract

The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-field gel electrophoresis. Daptomycin nonsusceptibility was confirmed by MIC and time-kill curve analyses.

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Figures

FIG. 1.
FIG. 1.
Pulsed-field gel electrophoresis. The lanes contain the following from left to right, respectively: marker strain NCTC 8325 (17), S. aureus A8796, S. aureus A8797, S. aureus A8798, and S. aureus A8799.
FIG. 2.
FIG. 2.
Time-kill curves for S. aureus A8796, A8797, A8798, and A8799 in the presence of 8 μg/ml daptomycin. The data at each time point represent the averages of two experiments.
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