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Review
. 2005 Aug;206(3):173-85.
doi: 10.1007/s00232-005-0792-1.

Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux

T W Loo  1 , D M Clarke
Affiliations
Review

Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux

T W Loo et al. J Membr Biol. 2005 Aug.

Abstract

P-glycoprotein (P-gp) is an ATP-dependent drug pump that can transport a broad range of hydrophobic compounds out of the cell. The protein is clinically important because of its contribution to the phenomenon of multidrug resistance during AIDS/HIV and cancer chemotherapy. P-gp is a member of the ATP-binding cassette (ABC) family of proteins. It is a single polypeptide that contains two repeats joined by a linker region. Each repeat has a transmembrane domain consisting of six transmembrane segments followed by a hydrophilic domain containing the nucleotide-binding domain. In this mini-review, we discuss recent progress in determining the structure and mechanism of human P-glycoprotein.

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References

    1. J Biol Chem. 2003 Oct 10;278(41):39706-10 - PubMed
    1. Biochemistry. 1994 Nov 29;33(47):14049-57 - PubMed
    1. J Biol Chem. 2004 Apr 30;279(18):18232-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10594-9 - PubMed
    1. J Biol Chem. 1998 Jul 3;273(27):16631-4 - PubMed

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