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. 1991 Jul;65(7):3911-4.
doi: 10.1128/JVI.65.7.3911-3914.1991.

The endogenous Mtv-8 provirus resides within the V kappa locus

J N Yang  1 , J P Dudley
Affiliations

The endogenous Mtv-8 provirus resides within the V kappa locus

J N Yang et al. J Virol. 1991 Jul.

Abstract

The endogenous Mtv-8 provirus previously has been mapped within approximately 0.52 centimorgan from several V kappa markers on mouse chromosome 6. Using Southern blotting and DNA from a recombinant backcross mouse from the C57BL/6 (Mtv-8 positive) and C58 (Mtv-8 negative) strains, Mtv-8 was localized to the same side of the crossover point as immunoglobulin kappa (Ig kappa)-V24 but on the opposite side of the crossover from Ig kappa-V10 and Ig kappa-V21. Molecular cloning and characterization of cellular DNA adjacent to Mtv-8 revealed a functional V kappa 9 gene approximately 4.6 kb downstream and in the same transcriptional orientation as the provirus. These data suggest that Mtv-8 is within the centromere-proximal portion of the V kappa locus.

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