Review
doi: 10.1016/j.smim.2006.01.005.
Epub 2006 Feb 3.
CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation
Affiliations
- PMID: 16458534
- PMCID: PMC1950263
- DOI: 10.1016/j.smim.2006.01.005
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Review
CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation
Semin Immunol.
2006 Apr.
Abstract
Induction of immunological tolerance to alloantigens would be the treatment of choice to prevent graft-versus-host disease (GvHD) and allograft rejection in transplantation medicine. Organisms use a variety of mechanisms to avoid potentially deadly immunity to self-antigens. The most potent self-tolerance mechanism is probably dominant tolerance assured by regulatory and suppressor T lymphocytes. It appears therefore attractive to use the same mechanism to induce transplantation-tolerance. We here review and discuss recent advances in the use of one of the best-characterized regulatory T lymphocyte populations, CD4(+)CD25(+) T cells, to prevent graft-versus-host disease and bone marrow allograft rejection.
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