Localization of major neutralizing epitopes on the S1 polypeptide of the murine coronavirus peplomer glycoprotein

doi:10.1016/0168-1702(91)90011-j

. 1991 Mar;18(2-3):99-107.

doi: 10.1016/0168-1702(91)90011-j.

Localization of major neutralizing epitopes on the S1 polypeptide of the murine coronavirus peplomer glycoprotein

S Takase-Yoden¹, T Kikuchi, S G Siddell, F Taguchi

Affiliations

PMID: 1645909
PMCID: PMC7133859
DOI: 10.1016/0168-1702(91)90011-j

Localization of major neutralizing epitopes on the S1 polypeptide of the murine coronavirus peplomer glycoprotein

S Takase-Yoden et al. Virus Res. 1991 Mar.

. 1991 Mar;18(2-3):99-107.

doi: 10.1016/0168-1702(91)90011-j.

Authors

S Takase-Yoden¹, T Kikuchi, S G Siddell, F Taguchi

Affiliation

¹ National Institute of Neuroscience, NCNP, Tokyo, Japan.

PMID: 1645909
PMCID: PMC7133859
DOI: 10.1016/0168-1702(91)90011-j

Abstract

A recombinant baculovirus system has been used to express the amino terminal half of the murine coronavirus (JHMV) peplomer glycoprotein in insect cells. The expressed polypeptide is glycosylated and is recognized by a set of monoclonal antibodies (mAbs) specific for JHMV S protein. Three of these mAbs have a very high neutralizing activity for JHMV but not for other MHV strains. These results indicate that JHMV-specific, major neutralizing epitopes reside in the amino terminal S1 subunit of the peplomer glycoprotein.

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References

1. Banner L.R., Keck J.G., Lai M.M.C. A clustering of RNA recombination sites adjacent to a hypervariable region of the peplomer gene of murine coronavirus. Virology. 1990;175:548–555. - PMC - PubMed
1. Cavanagh D., Davis P.J., Darbyshire J.H., Peter R.W. Coronavirus IBV: virus retaining spike glycopolypeptide S2 but not S1 is unable to induce virus-neutralizing or hemagglutination-in- hibiting antibody, or induce chicken tracheal protection. J. Gen. Virol. 1986;67:1435–1442. - PubMed
1. Collins A.R., Knobler R.L., Powell H., Buchmeier M.J. Monoclonal antibodies to murine hepatitis virus-4 (strain JHM) define the viral glycoprotein responsible for attachment and cell-cell fusion. Virology. 1982;119:358–371. - PMC - PubMed
1. Dalziel R.G., Lampert P.W., Talbot P.J., Buchmeier M.J. Site specific alteration of murine hepatitis virus type-4 (MHV-4) peplomer glycoprotein E2 results in reduced neurovirulence. J. Virol. 1986;59:463–471. - PMC - PubMed
1. Delmas B., Rasschaert D., Godet M., Gelfi J., Laude H. Four major antigenic sites of the coronavirus transmissible gastroenteritis virus are located on the amino-terminal half of spike glycoprotein S. J. Gen. Virol. 1990;71:1313–1323. - PubMed

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[1] Banner L.R., Keck J.G., Lai M.M.C. A clustering of RNA recombination sites adjacent to a hypervariable region of the peplomer gene of murine coronavirus. Virology. 1990;175:548–555. - PMC - PubMed

[2] Banner L.R., Keck J.G., Lai M.M.C. A clustering of RNA recombination sites adjacent to a hypervariable region of the peplomer gene of murine coronavirus. Virology. 1990;175:548–555. - PMC - PubMed

[3] Cavanagh D., Davis P.J., Darbyshire J.H., Peter R.W. Coronavirus IBV: virus retaining spike glycopolypeptide S2 but not S1 is unable to induce virus-neutralizing or hemagglutination-in- hibiting antibody, or induce chicken tracheal protection. J. Gen. Virol. 1986;67:1435–1442. - PubMed

[4] Cavanagh D., Davis P.J., Darbyshire J.H., Peter R.W. Coronavirus IBV: virus retaining spike glycopolypeptide S2 but not S1 is unable to induce virus-neutralizing or hemagglutination-in- hibiting antibody, or induce chicken tracheal protection. J. Gen. Virol. 1986;67:1435–1442. - PubMed

[5] Collins A.R., Knobler R.L., Powell H., Buchmeier M.J. Monoclonal antibodies to murine hepatitis virus-4 (strain JHM) define the viral glycoprotein responsible for attachment and cell-cell fusion. Virology. 1982;119:358–371. - PMC - PubMed

[6] Collins A.R., Knobler R.L., Powell H., Buchmeier M.J. Monoclonal antibodies to murine hepatitis virus-4 (strain JHM) define the viral glycoprotein responsible for attachment and cell-cell fusion. Virology. 1982;119:358–371. - PMC - PubMed

[7] Dalziel R.G., Lampert P.W., Talbot P.J., Buchmeier M.J. Site specific alteration of murine hepatitis virus type-4 (MHV-4) peplomer glycoprotein E2 results in reduced neurovirulence. J. Virol. 1986;59:463–471. - PMC - PubMed

[8] Dalziel R.G., Lampert P.W., Talbot P.J., Buchmeier M.J. Site specific alteration of murine hepatitis virus type-4 (MHV-4) peplomer glycoprotein E2 results in reduced neurovirulence. J. Virol. 1986;59:463–471. - PMC - PubMed

[9] Delmas B., Rasschaert D., Godet M., Gelfi J., Laude H. Four major antigenic sites of the coronavirus transmissible gastroenteritis virus are located on the amino-terminal half of spike glycoprotein S. J. Gen. Virol. 1990;71:1313–1323. - PubMed

[10] Delmas B., Rasschaert D., Godet M., Gelfi J., Laude H. Four major antigenic sites of the coronavirus transmissible gastroenteritis virus are located on the amino-terminal half of spike glycoprotein S. J. Gen. Virol. 1990;71:1313–1323. - PubMed

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Localization of major neutralizing epitopes on the S1 polypeptide of the murine coronavirus peplomer glycoprotein

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Localization of major neutralizing epitopes on the S1 polypeptide of the murine coronavirus peplomer glycoprotein

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