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Comment
. 2006 Feb;10(2):151-2.
doi: 10.1016/j.devcel.2006.01.005.

Open sesame! Coxsackieviruses conspire to trespass the tight junctional gate

Fernando Diaz  1 , Enrique Rodriguez-Boulan
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Open sesame! Coxsackieviruses conspire to trespass the tight junctional gate

Fernando Diaz et al. Dev Cell. 2006 Feb.
Free article

Abstract

In the January 13 issue of Cell, Coyne and Bergelson describe an "Open sesame!" strategy developed by coxsackieviruses to invade the organism through the intestinal epithelium. The strategy involves coopting intrinsic signaling abilities of the apical GPI-anchored protein DAF to open the tight junction barrier, gain access to the primary receptor CAR, and activate virus internalization by a caveolin-dependent pathway.

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