doi: 10.1016/0014-5793(91)80602-y.
Diazipine, a novel photoaffinity probe for dihydropyridine receptors of calcium channels
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- PMID: 1646123
- DOI: 10.1016/0014-5793(91)80602-y
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Diazipine, a novel photoaffinity probe for dihydropyridine receptors of calcium channels
FEBS Lett.
.
Free article
Abstract
A new 1,4-dihydropyridine photoaffinity ligand, [3H]diazipine, has been assessed by binding and photolabeling, and compared with a currently used [3H]azidopine. [3H]Diazipine reversibly binds to skeletal muscle Ca2+ channels with a similar affinity to [3H]azidopine, but [3H]diazipine labels the channel two times more efficiently and no release of the incorported amount is observed after dithiothreitol treatment.
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