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. 1991 Jun 3;283(2):259-62.
doi: 10.1016/0014-5793(91)80602-y.

Diazipine, a novel photoaffinity probe for dihydropyridine receptors of calcium channels

M Taki  1 , H Nakayama, Y Kanaoka
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Free article

Diazipine, a novel photoaffinity probe for dihydropyridine receptors of calcium channels

M Taki et al. FEBS Lett. .
Free article

Abstract

A new 1,4-dihydropyridine photoaffinity ligand, [3H]diazipine, has been assessed by binding and photolabeling, and compared with a currently used [3H]azidopine. [3H]Diazipine reversibly binds to skeletal muscle Ca2+ channels with a similar affinity to [3H]azidopine, but [3H]diazipine labels the channel two times more efficiently and no release of the incorported amount is observed after dithiothreitol treatment.

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