Review
doi: 10.1016/j.cub.2006.01.022.
Tumor suppressors: control of signaling by endocytosis
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- PMID: 16461271
- DOI: 10.1016/j.cub.2006.01.022
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Review
Tumor suppressors: control of signaling by endocytosis
Curr Biol.
.
Free article
Abstract
Genetic defects of the endosomal 'ESCRT' machinery in Drosophila have been found to cause loss of epithelial cell polarity, accompanied by overproliferation of mutant and adjacent wild-type cells. These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch.
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