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Review
. 2006 Feb 7;16(3):R91-2.
doi: 10.1016/j.cub.2006.01.022.

Tumor suppressors: control of signaling by endocytosis

Bernd Giebel  1 , Andreas Wodarz
Affiliations
Free article
Review

Tumor suppressors: control of signaling by endocytosis

Bernd Giebel et al. Curr Biol. .
Free article

Abstract

Genetic defects of the endosomal 'ESCRT' machinery in Drosophila have been found to cause loss of epithelial cell polarity, accompanied by overproliferation of mutant and adjacent wild-type cells. These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch.

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