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Review
. 2006 Feb;82(964):84-8.
doi: 10.1136/pgmj.2005.036665.

Ageing and the brain

R Peters  1
Affiliations
Review

Ageing and the brain

R Peters. Postgrad Med J. 2006 Feb.

Abstract

Ageing causes changes to the brain size, vasculature, and cognition. The brain shrinks with increasing age and there are changes at all levels from molecules to morphology. Incidence of stroke, white matter lesions, and dementia also rise with age, as does level of memory impairment and there are changes in levels of neurotransmitters and hormones. Protective factors that reduce cardiovascular risk, namely regular exercise, a healthy diet, and low to moderate alcohol intake, seem to aid the ageing brain as does increased cognitive effort in the form of education or occupational attainment. A healthy life both physically and mentally may be the best defence against the changes of an ageing brain. Additional measures to prevent cardiovascular disease may also be important.

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Conflict of interest statement

Conflicts of interest: none.

References

    1. Svennerholm L, Boström K, Jungbjer B. Changes in weight and compositions of major membrane components of human brain during the span of adult human life of Swedes. Acta Neuropathol 199794345–352. - PubMed
    1. Scahill R, Frost C, Jenkins R.et al A longitudinal study of brain volume changes in normal ageing using serial registered magnetic resonance imaging. Arch Neurol 200360989–994. - PubMed
    1. Raz N. The ageing brain: structural changes and their implications for cognitive ageing. In: Dixon R, Bäckman L, Nilsson L, eds. New frontiers in cognitive ageing. Oxford: Oxford University Press, 2004115–134.
    1. Anderton B. Ageing of the brain. Mech Ageing Dev 2002123811–817. - PubMed
    1. Kolb B, Wishaw I. Brain plasticity and behaviour. Annu Rev Psychol 19984943–64. - PubMed

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