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Review
. 2005;33(3):223-39.
doi: 10.1385/IR:33:3:223.

Role of nitric oxide in mast cells: controversies, current knowledge, and future applications

Yokananth Sekar  1 , Tae Chul Moon, Samira Muñoz, A Dean Befus
Affiliations
Review

Role of nitric oxide in mast cells: controversies, current knowledge, and future applications

Yokananth Sekar et al. Immunol Res. 2005.

Abstract

Mast cells (MC) are important effector cells in allergic disorders. Recently, the role of MC in innate and adaptive immunity is gaining prominence. Nitric oxide is an important signaling molecule and its production in mast cell has been reported widely. However, controversy exists about whether MC produce NO. This review addresses the role of NO in MC biology and the reasons behind the controversy and discusses effects of NO in regulation of MC phenotype and function.

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