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Comparative Study
. 2006 Feb:443:73-4.
doi: 10.1097/01.blo.0000200242.52802.6d.

Beta-blockers increase bone mineral density

Sonay Turker  1 , Vasfi Karatosun, Izge Gunal
Affiliations
Comparative Study

Beta-blockers increase bone mineral density

Sonay Turker et al. Clin Orthop Relat Res. 2006 Feb.

Abstract

Authors of animal studies suggest that beta-blockers stimulate bone formation and inhibit bone resorption. On the other hand, data in humans are limited and conflicting results exist in literature. We conducted a prospective case-control study in order to investigate the effects of beta-blockers on bone mineral density in the elderly population. None of the patients were receiving anti-resorptive medicine. Bone mineral density of 50 beta-blocker users was significantly greater at all measured skeletal sites compared with 100 nonusers. Bone mineral density for total hip and spine (beta-blocker users and nonusers) were, 0.85 +/- 0.13, 0.80 +/- 0.11 and 0.90 +/- 0.15, 0.83 +/- 0.12, respectively. Our results suggest that use of beta-blockers is associated with an increase in bone mineral density.

Level of evidence: Therapeutic study, LEVEL III (case control study). See the Guidelines for Authors for a complete description of the levels of evidence.

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