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Review
. 2006 Feb;106(2):277-301.
doi: 10.1021/cr040478b.

Formation and repair of interstrand cross-links in DNA

David M Noll  1 , Tracey McGregor Mason, Paul S Miller
Affiliations
Review

Formation and repair of interstrand cross-links in DNA

David M Noll et al. Chem Rev. 2006 Feb.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Interstrand cross-linked DNA.
Figure 2
Figure 2
Basic DNA repair pathways.
Figure 3
Figure 3
Clastogenic effects of interstrand cross-linking agents.
Figure 4
Figure 4
Compounds that can form DNA interstrand cross-links.
Figure 5
Figure 5
Phosphamide mustards.
Figure 6
Figure 6
Nitrogen mustard interstrand cross-link.
Figure 7
Figure 7
Reactions of N7-alkylated guanine.
Figure 8
Figure 8
Formation of mitomycin C interstrand cross-link.
Figure 9
Figure 9
cis-Diamminedichloro- and trans-diamminedichloroplatinum interstrand cross-links.
Figure 10
Figure 10
Psoralens and their DNA photoadducts.
Figure 11
Figure 11
Nucleotide excision repair in E. coli.
Figure 12
Figure 12
Homologous recombination.
Figure 13
Figure 13
Translesion synthesis.
Figure 14
Figure 14
Model for interstrand cross-link repair in E. coli. The furan adduct is indicated by the square, and the pyrone adduct is indicated by the circle.
Figure 15
Figure 15
In vitro strand exchange reactions with psoralen cross-linked DNA. The furan adduct is indicated by the square, and the pyrone adduct is indicated by the circle.
Figure 16
Figure 16
N-Methylmitomycin A.
Figure 17
Figure 17
Nitrogen mustard interstrand cross-link repair in E. coli.
Figure 18
Figure 18
N4C-Ethyl-N4C interstrand cross-link.
Figure 19
Figure 19
Interstrand cross-link repair pathways in S. cerevisiae.
Figure 20
Figure 20
Cross-link-induced DNA strand breaks.
See this image and copyright information in PMC

References

    1. Lawley PD, Phillips DH. Mutat Res. 1996;355:13–40. - PubMed
    1. Murnane JP, Byfield JE. Chem Biol Interact. 1981;38:75–86. - PubMed
    1. Erickson LC, Bradley MO, Ducore JM, Ewig RAG, Kohn KW. Proc Natl Acad Sci USA. 1980;77:467–471. - PMC - PubMed
    1. Garcia ST, McQuillan A, Panasci L. Biochem Pharmacol. 1988;37:3189–3192. - PubMed
    1. O’Connor PM, Kohn KW. Cancer Commun. 1990;2:387–394. - PubMed

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