This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Review

. 2006 Feb;106(2):687-99.

doi: 10.1021/cr040498d.

DNA ligases: structure, reaction mechanism, and function

Alan E Tomkinson¹, Sangeetha Vijayakumar, John M Pascal, Tom Ellenberger

Affiliations

Affiliation

¹ Radiation Oncology Research Laboratory and Marlene and Stewart Greenebaum Cancer Center, Molecular and Cellular Biology Graduate Program, University of Maryland School of Medicine, Baltimore, 21201, USA. atomkinson@som.umaryland.edu

PMID: 16464020
DOI: 10.1021/cr040498d

Review

DNA ligases: structure, reaction mechanism, and function

Alan E Tomkinson et al. Chem Rev. 2006 Feb.

. 2006 Feb;106(2):687-99.

doi: 10.1021/cr040498d.

Authors

Alan E Tomkinson¹, Sangeetha Vijayakumar, John M Pascal, Tom Ellenberger

Affiliation

¹ Radiation Oncology Research Laboratory and Marlene and Stewart Greenebaum Cancer Center, Molecular and Cellular Biology Graduate Program, University of Maryland School of Medicine, Baltimore, 21201, USA. atomkinson@som.umaryland.edu

PMID: 16464020
DOI: 10.1021/cr040498d

No abstract available

PubMed Disclaimer

Similar articles

DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III.
Mackey ZB, Niedergang C, Murcia JM, Leppard J, Au K, Chen J, de Murcia G, Tomkinson AE. Mackey ZB, et al. J Biol Chem. 1999 Jul 30;274(31):21679-87. doi: 10.1074/jbc.274.31.21679. J Biol Chem. 1999. PMID: 10419478
Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate.
Nandakumar J, Nair PA, Shuman S. Nandakumar J, et al. Mol Cell. 2007 Apr 27;26(2):257-71. doi: 10.1016/j.molcel.2007.02.026. Mol Cell. 2007. PMID: 17466627
DNA ligases in the repair and replication of DNA.
Timson DJ, Singleton MR, Wigley DB. Timson DJ, et al. Mutat Res. 2000 Aug 30;460(3-4):301-18. doi: 10.1016/s0921-8777(00)00033-1. Mutat Res. 2000. PMID: 10946235 Review.
Different active sites of mammalian DNA ligases I and II.
Roberts E, Nash RA, Robins P, Lindahl T. Roberts E, et al. J Biol Chem. 1994 Feb 4;269(5):3789-92. J Biol Chem. 1994. PMID: 8106423
Structure and function of the DNA ligases encoded by the mammalian LIG3 gene.
Tomkinson AE, Sallmyr A. Tomkinson AE, et al. Gene. 2013 Dec 1;531(2):150-7. doi: 10.1016/j.gene.2013.08.061. Epub 2013 Sep 5. Gene. 2013. PMID: 24013086 Free PMC article. Review.

See all similar articles

Cited by

Identification of Novel Inhibitors of Escherichia coli DNA Ligase (LigA).
Alomari A, Gowland R, Southwood C, Barrow J, Bentley Z, Calvin-Nelson J, Kaminski A, LeFevre M, Callaghan AJ, Vincent HA, Gowers DM. Alomari A, et al. Molecules. 2021 Apr 25;26(9):2508. doi: 10.3390/molecules26092508. Molecules. 2021. PMID: 33923034 Free PMC article.
Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH.
Englert M, Xia S, Okada C, Nakamura A, Tanavde V, Yao M, Eom SH, Konigsberg WH, Söll D, Wang J. Englert M, et al. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15235-40. doi: 10.1073/pnas.1213795109. Epub 2012 Sep 4. Proc Natl Acad Sci U S A. 2012. PMID: 22949672 Free PMC article.
Virtual screening of specific chemical compounds by exploring E.coli NAD+-dependent DNA ligase as a target for antibacterial drug discovery.
Akhoon BA, Gupta SK, Dhaliwal G, Srivastava M, Gupta SK. Akhoon BA, et al. J Mol Model. 2011 Feb;17(2):265-73. doi: 10.1007/s00894-010-0713-9. Epub 2010 May 5. J Mol Model. 2011. PMID: 20443037
Introducing cloned genes into cultured neurons providing novel in vitro models for neuropathology and neurotoxicity studies.
Farina M, Berenguer J, Pons S, da Rocha JBT, Aschner M. Farina M, et al. Neuromethods. 2011;56:185-222. doi: 10.1007/978-1-61779-077-5_9. Epub 2011 Feb 14. Neuromethods. 2011. PMID: 32132768 Free PMC article. No abstract available.
Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising.
Jekimovs C, Bolderson E, Suraweera A, Adams M, O'Byrne KJ, Richard DJ. Jekimovs C, et al. Front Oncol. 2014 Apr 22;4:86. doi: 10.3389/fonc.2014.00086. eCollection 2014. Front Oncol. 2014. PMID: 24795863 Free PMC article. Review.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
- American Chemical Society
Other Literature Sources
- The Lens - Patent Citations Database
Molecular Biology Databases
- GlyGen glycoinformatics resource