Review
doi: 10.1016/j.coi.2006.01.008.
Epub 2006 Feb 7.
AID in somatic hypermutation and class switch recombination
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- PMID: 16464563
- DOI: 10.1016/j.coi.2006.01.008
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Review
AID in somatic hypermutation and class switch recombination
Curr Opin Immunol.
2006 Apr.
Abstract
Somatic hypermutation and class-switch-recombination are initiated by the deamination of deoxycytosine in DNA by activation-induced-deaminase, AID. Recently, there has been much research into how AID targets double-stranded DNA in sub-regions of Ig genes, the involvement of co-factors and posttranslational modifications in this process, the co-option of DNA 'repair' mechanisms and AID evolution.
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