Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2006 Jun;90(6):674-8.
doi: 10.1136/bjo.2005.086769. Epub 2006 Feb 7.

Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex

N Gupta  1 , L-C Ang, L Noël de Tilly, L Bidaisee, Y H Yücel
Affiliations
Case Reports

Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex

N Gupta et al. Br J Ophthalmol. 2006 Jun.

Abstract

The pathology of glaucoma has been extensively studied at the level of the retina and optic nerve head. Here the first clinicopathological case of human glaucoma is reported demonstrating degenerative changes in the brain involving the intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Pathological evidence of neural degeneration in this patient is correlated with clinical, optic nerve head, visual field, and neuroradiology findings. Neuropathology in the glaucoma brain is compared to age matched controls. In the presence of advanced human glaucoma with 50% visual field loss, neural damage is evident in multiple vision stations within the brain.

PubMed Disclaimer

Conflict of interest statement

Competing interest statement: there are no competing interests to be declared.

Comment in

References

    1. Yücel Y H, Zhang Q, Gupta N.et al Loss of neurons in magnocellular and parvocellular layers of the LGN in glaucoma. Arch Ophthalmol 2000118378–384. - PubMed
    1. Weber A J, Chen H, Hubbard W C.et al Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus. Invest Ophthalmol Vis Sci 2000411370–1379. - PubMed
    1. Crawford M L, Harwerth R S, Smith E L., 3rdet al Glaucoma in primates: cytochrome oxidase reactivity in parvo‐ and magnocellular pathways. Invest Ophthal Vis Sci 2000411791–1802. - PubMed
    1. Yücel Y H, Zhang Q, Weinreb R N.et al Atrophy of relay neurons in magno‐ and parvocellular layers in the lateral geniculate nucleus in experimental glaucoma. Invest Ophthalmol Vis Sci 2001423216–3222. - PubMed
    1. Gupta N, Yücel Y H. Glaucoma and the brain. J Glaucoma 200110S28–S29. - PubMed

Publication types