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. 2006 Jul;127(1):94-8.
doi: 10.1016/j.ejogrb.2005.12.023. Epub 2006 Feb 8.

Optimizing hCG cut-off values: a single determination on day 14 or 15 is sufficient for a reliable prediction of pregnancy outcome

Marieke J Lambers  1 , Hans G I van Weering, Maud S van't Grunewold, Cornelis B Lambalk, Roy Homburg, Roel Schats, Peter G A Hompes
Affiliations

Optimizing hCG cut-off values: a single determination on day 14 or 15 is sufficient for a reliable prediction of pregnancy outcome

Marieke J Lambers et al. Eur J Obstet Gynecol Reprod Biol. 2006 Jul.

Abstract

Objective: Optimizing the cut-off level for a single serum hCG determination around day 15 after oocyte retrieval or ovulation.

Study design: Retrospective data analysis.

Results: 204 hCG samples >5 IU/L between March and October 1999 taken on day 14, 15 or 16 after oocyte retrieval in 204 patients undergoing IVF or ICSI were analyzed. ROC-curves and optimal cut-off levels to discriminate between viable and non-viable pregnancies were calculated for each day separately. Cut-off levels were found at 76, 142 and 223 IU/L for day 14, 15 and 16, respectively, and were verified by 487 hCG samples >5 IU/L taken between January 2000 and June 2004.

Conclusions: A single serum hCG determination on day 14 or 15 is sufficient to discriminate viable pregnancies accurately from non-viable pregnancies.

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