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Comment
. 2006 Feb 10;124(3):459-61.
doi: 10.1016/j.cell.2006.01.022.

Rejuvenating exhausted T cells during chronic viral infection

Taku Okazaki  1 , Tasuku Honjo
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Rejuvenating exhausted T cells during chronic viral infection

Taku Okazaki et al. Cell. .
Free article

Abstract

In a recent paper in Nature, show that the immunoreceptor PD-1 is upregulated by "exhausted" T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load.

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