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. 2006 Feb;21(2):136-41.
doi: 10.1002/mds.20861.

Crossroads in GDNF therapy for Parkinson's disease

Todd B Sherer  1 , Brian K Fiske, Clive N Svendsen, Anthony E Lang, J William Langston
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Crossroads in GDNF therapy for Parkinson's disease

Todd B Sherer et al. Mov Disord. 2006 Feb.

Abstract

The development of a neuroprotective or neuroregenerative therapy for Parkinson's disease (PD) would be a major therapeutic advance. Unfortunately, results from a recent controlled clinical study delivering the neurotrophic factor, glial-derived neurotrophic factor (GDNF), directly into brain did not demonstrate efficacy and safety of such a treatment. A critical review of available data suggests that there are questions that need to be answered before the future of GDNF as a therapy for PD can be determined.

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