Review
doi: 10.1016/j.tcm.2005.12.001.
Atherosclerosis and the Lectin-like OXidized low-density lipoprotein scavenger receptor
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- PMID: 16473764
- DOI: 10.1016/j.tcm.2005.12.001
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Review
Atherosclerosis and the Lectin-like OXidized low-density lipoprotein scavenger receptor
Trends Cardiovasc Med.
2006 Feb.
Abstract
The Lectin-like OXidized low-density lipoprotein scavenger receptor (LOX-1) is implicated in vascular inflammation and atherosclerotic plaque initiation, progression, and destabilization. LOX-1 levels are elevated upon recognition of oxidized low-density lipoprotein, a key pro-atherogenic substance in the vasculature. Recent evidence indicates this gene product is a biomarker of inflammation and disease status. We review and assess the role of LOX-1 in atherosclerotic plaque formation, physiologic regulation, and as a biomarker and target in cardiovascular disease diagnosis and prevention.
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