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. 2006 Feb;14(2):176-80.
doi: 10.1097/01.JGP.0000192484.12684.cd.

Adherence to continuous positive airway pressure treatment in patients with Alzheimer's disease and obstructive sleep apnea

Liat Ayalon  1 , Sonia Ancoli-Israel, Carl Stepnowsky, Matthew Marler, Barton W Palmer, Lianqi Liu, Jose S Loredo, Jody Corey-Bloom, Deborah Greenfield, Jana Cooke
Affiliations

Adherence to continuous positive airway pressure treatment in patients with Alzheimer's disease and obstructive sleep apnea

Liat Ayalon et al. Am J Geriatr Psychiatry. 2006 Feb.

Abstract

Objective: This analysis examined whether patients with Alzheimer disease (AD) tolerate continuous positive airway pressure (CPAP).

Method: Thirty patients with AD were randomized to CPAP or sham CPAP and completed sleep, depression, and quality-of-life questionnaires. Participants could choose to continue treatment after the trial.

Results: Patients wore CPAP for 4.8 hours per night. More depressive symptoms were associated with worse adherence (rS=-0.37; N=30, p<0.04). Patients who continued using CPAP had fewer depressive symptoms (t [19]=2.45, p=0.02) and better adherence (t [19]=2.32, p=0.03) during the trial.

Conclusion: Patients with AD with obstructive sleep apnea can tolerate CPAP. Adherence and long-term use may be more difficult among those patients with more depressive symptoms.

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