Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975;119(1):1-3.
doi: 10.1007/BF00464689.

Unsuccessful trial of gene replacement in arginase deficiency

H G Terheggen, A Lowenthal, F Lavinha, J P Colombo, S Rogers

Unsuccessful trial of gene replacement in arginase deficiency

H G Terheggen et al. Z Kinderheilkd. 1975.

Abstract

The Shope virus following cutaneous inoculation produces skin papillomas in rabbits and induces a virus-coded arginase in the squameous epithelium of these papillomas. The only discernible effect of the virus inoculated intravenously in rabbits and other animals was a decrease of the serum arginine concentration. Intravenous injection in 3 hyperargininemic patients, however, did not influence the underlying metabolic disease.

PubMed Disclaimer

References

    1. Nature. 1966 Dec 10;212(5067):1220-2 - PubMed
    1. J Exp Med. 1971 Dec 1;134(6):1442-52 - PubMed
    1. Nature. 1959 Jun 27;183:1815-6 - PubMed
    1. Science. 1972 Nov 10;178(4061):648-9 - PubMed
    1. Z Kinderheilkd. 1970;107(4):313-23 - PubMed