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. 2006 Oct;134(5):961-6.
doi: 10.1017/S0950268805005844. Epub 2006 Feb 14.

Antibiogram pattern and seasonality of Salmonella serotypes in a North Indian tertiary care hospital

S Mohanty  1 , K Renuka, S Sood, B K DAS, A Kapil
Affiliations

Antibiogram pattern and seasonality of Salmonella serotypes in a North Indian tertiary care hospital

S Mohanty et al. Epidemiol Infect. 2006 Oct.

Abstract

The antibiogram pattern and seasonal distribution of Salmonella serotypes were analysed retrospectively over a 6-year period from January 1999 to December 2004. Blood cultures received in the Bacteriology Laboratory were processed by standard procedures and the Salmonella spp. isolates were identified with specific antisera and standard biochemical tests. Antimicrobial susceptibility testing was carried out by a standard disc diffusion method and the minimum inhibitory concentration (MIC) of ciprofloxacin for 332 representative Salmonella isolates was determined by E test. Salmonella Typhi (75.7%) was the predominant serotype among 830 Salmonella spp. isolated during the study period followed by S. Paratyphi A (23.8%). The maximum number of enteric fever cases occurred during April-June (dry season) followed by July-September (monsoon season). There was a decrease in multidrug-resistant (MDR) S. Typhi, but MDR S. Paratyphi A isolates increased. There was also a dramatic increase in nalidixic acid-resistant isolates. All isolates were susceptible to third-generation cephalosporins and ciprofloxacin except one S. Typhi strain which demonstrated high-level ciprofloxacin resistance with a MIC of 16 mug/ml. A knowledge of the seasonal distribution and antibiotic resistance pattern of Salmonella in a particular geographical region is helpful in the delineation of appropriate control measures required for prevention of enteric fever.

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Figures

Fig. 1
Fig. 1
Isolation rates of S. Typhi, by year and month in Delhi, India, 1999–2004.
Fig. 2
Fig. 2
Isolation rates of S. Paratyphi A, by year and month in Delhi, India, 1999–2004.
See this image and copyright information in PMC

References

    1. Miller SI, Pegues DA, Mandell GL, Bennet JE, Dolin R. Principles and Practice of Infectious Disease. 4th edn. New York: Churchill Livingstone; 1998. Salmonella species, including Salmonella typhi; pp. 2344–2373. : pp.
    1. Ivanoff B. Typhoid fever, global situation and WHO recommendations. Southeast Asian Journal of Tropical Medicine and Public Health. 1995;26:1–6. (Suppl 2):
    1. Richens J, Weatherale DJ, Ledingham JGG, Warrell DA. Oxford Textbook of Medicine. 3rd edn. Vol. 1. London: Oxford Medical Publication; 1996. Typhoid and paratyphoid fevers; pp. 560–568. , vol. : pp.
    1. Mirza SH. The prevalence and clinical features of multi-drug resistant Salmonella typhi infections in Baluchistan, Pakistan. Annals of Tropical Medicine and Parasitology. 1995;89:515–519. - PubMed
    1. Mermin JH et al. Typhoid fever in the United States 1985–1994: changing risks of international travel and increasing antimicrobial resistance. Archives of Internal Medicine. 1998;158:633–638. - PubMed

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