Comment
doi: 10.1016/j.neuron.2006.01.028.
A new peptide input to learning and addiction
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- PMID: 16476658
- DOI: 10.1016/j.neuron.2006.01.028
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A new peptide input to learning and addiction
Neuron.
.
Free article
Abstract
In this issue of Neuron, Borgland et al. report that the arousal-associated peptide orexin enhances LTP-like changes in glutamatergic excitability of ventral tegmental dopamine neurons. This parallels a similar effect of corticotropin-releasing factor and suggests a form of neuroadaptation that increases the likelihood of addiction relapse.
Comment on
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Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.Neuron. 2006 Feb 16;49(4):589-601. doi: 10.1016/j.neuron.2006.01.016. Neuron. 2006. PMID: 16476667
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