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. 2006 Feb 14;66(3):424-6.
doi: 10.1212/01.wnl.0000196464.47508.00.

Pontine and cerebellar atrophy correlate with clinical disability in SCA2

S H Ying  1 , S I Choi, S L Perlman, R W Baloh, D S Zee, A W Toga
Affiliations

Pontine and cerebellar atrophy correlate with clinical disability in SCA2

S H Ying et al. Neurology. .

Abstract

Spinocerebellar ataxia type 2 (SCA2) has protean manifestations, and a clinical marker of progression is needed. Although MRI is a promising tool, it is unclear whether the degree of atrophy shown on MRI is correlated with clinical dysfunction. Here the authors used high-resolution volumetric MRI analysis to show that cerebellar and pontine volumes specifically and closely correlate with functional staging scores.

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