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. 1991 Mar;55(2):137-40.
doi: 10.1016/0163-1047(91)80134-z.

Phosphatidylserine increases the affinity of the AMPA/quisqualate receptor in rat brain membranes

M Baudry  1 , G Massicotte, S Hauge
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Phosphatidylserine increases the affinity of the AMPA/quisqualate receptor in rat brain membranes

M Baudry et al. Behav Neural Biol. 1991 Mar.

Abstract

We investigated the effects of phospholipids and cholesterol on the binding of [3H]-AMPA to rat telencephalic membranes. Phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, and cholesterol were without effect at concentrations up to 1.5 mg/mg protein. Only phosphatidylserine increased [3H]-AMPA binding in a dose-dependent manner. This effect was due to an increase in the affinity of the low affinity component of [3H]-AMPA binding. These results indicate that the distribution of phosphatidylserine in membranes modulates the properties of the AMPA/quisqualate receptor.

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