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. 1991 Jun 28;177(3):1165-70.
doi: 10.1016/0006-291x(91)90662-q.

Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid

J Yatsunami  1 , H Fujiki, M Suganuma, S Yoshizawa, J E Eriksson, M O Olson, R D Goldman
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Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid

J Yatsunami et al. Biochem Biophys Res Commun. .

Abstract

Okadaic acid and dinophysistoxin-1 (35-methylokadaic acid) induced hyperphosphorylation of a 58 kDa protein in primary human fibroblasts, due to inhibition of protein phosphatase 1 and 2A activities. The protein was present in the nuclear and cytosolic fractions. Its pI was 5.3. The hyperphosphorylated protein reacted with monoclonal and polyclonal anti-vimentin antibodies, but not with anti-nucleolin antibody. Phosphorylation of vimentin was stimulated in vitro by dinophysistoxin-1 dose-dependently in the presence of protein phosphatase 2A and protein kinases.

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